万能ペルオキシダーゼ

万能ペルオキシダーゼ（ばんのうペルオキシダーゼ、versatile peroxidase）は、次の化学反応を触媒する酸化還元酵素である。

万能ペルオキシダーゼ
識別子
EC番号	1.11.1.16
CAS登録番号	42613-30-9
データベース
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB構造	RCSB PDB PDBj PDBe PDBsum
遺伝子オントロジー	AmiGO / QuickGO
検索 PMC articles PubMed articles NCBI proteins

(1) リアクティブブラック5 + H₂O₂ $\rightleftharpoons$ 酸化型リアクティブブラック5 + 2 H₂O

(2) 供与体 + H₂O₂ $\rightleftharpoons$ 酸化型供与体 + 2 H₂O

組織名はreactive-black-5:hydrogen-peroxide oxidoreductaseで、別名にVP、hybrid peroxidase、polyvalent peroxidaseがある。

参考文献

• Martínez, M.J., Ruiz-Dueñas, F.J., Guillén, F. and Martínez, A.T. (1996). “Purification and catalytic properties of two manganese peroxidase isoenzymes from Pleurotus eryngii.”. Eur. J. Biochem. 237: 424-432. PMID 8647081. 
• Heinfling, A., Ruiz-Dueñas, F.J., Martínez, M.J., Bergbauer, M., Szewzyk, U. and Martínez, A.T. (1998). “A study on reducing substrates of manganese-oxidizing peroxidases from Pleurotus eryngii and Bjerkandera adusta.”. FEBS Lett. 428: 141-146. PMID 9654123. 
• Ruiz-Due̱as, F.J., Martínez, M.J. and Martínez, A.T. (31). “Molecular characterization of a novel peroxidase isolated from the ligninolytic fungus Pleurotus eryngii.”. Mol. Microbiol. 31: 223-235. PMID 9987124. 
• Camarero, S., Sarkar, S., Ruiz-Dueñas, F.J., Martínez, M.J. and Martínez, A.T. (1999). “Description of a versatile peroxidase involved in the natural degradation of lignin that has both manganese peroxidase and lignin peroxidase substrate interaction sites.”. J. Biol. Chem. 274: 10324-10330. PMID 10187820. 
• Ruiz-Dueñas, F.J., Martínez, M.J. and Martínez, A.T. (1999). “Heterologous expression of Pleurotus eryngii peroxidase confirms its ability to oxidize Mn²⁺ and different aromatic substrates.”. Appl. Environ. Microbiol. 65: 4705-4707. PMID 10508113. 
• Camarero, S., Ruiz-Dueñas, F.J., Sarkar, S., Martínez, M.J. and Martínez, A.T. (2000). “The cloning of a new peroxidase found in lignocellulose cultures of Pleurotus eryngii and sequence comparison with other fungal peroxidases.”. FEMS Microbiol. Lett. 191: 37-43. PMID 11004397. 
• Ruiz-Dueñas, F.J., Camarero, S., Pérez-Boada, M., Martínez, M.J. and Martínez, A.T. (2001). “A new versatile peroxidase from Pleurotus. Biochem.”. Soc. Trans. 29: 116-122. PMID 11356138. 
• Banci, L., Camarero, S., Martínez, A.T., Martínez, M.J., Pérez-Boada, M., Pierattelli, R. and Ruiz-Dueñas, F.J. (2003). “NMR study of manganese(II) binding by a new versatile peroxidase from the white-rot fungus Pleurotus eryngii.”. J. Biol. Inorg. Chem. 8: 751-760. PMID 12884090. 
• Pérez-Boada, M., Ruiz-Dueñas, F.J., Pogni, R., Basosi, R., Choinowski, T., Martínez, M.J., Piontek, K. and Martínez, A.T. (2005). “Versatile peroxidase oxidation of high redox potential aromatic compounds: site-directed mutagenesis, spectroscopic and crystallographic investigation of three long-range electron transfer pathways.”. J. Mol. Biol. 354: 385-402. PMID 16246366.