4-ヒドロキシ安息香酸-3-モノオキシゲナーゼ
4-ヒドロキシ安息香酸-3-モノオキシゲナーゼ（4-hydroxybenzoate 3-monooxygenase）は、次の化学反応を触媒する酸化還元酵素である。
| 4-ヒドロキシ安息香酸-3-モノオキシゲナーゼ | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| 識別子 | |||||||||
| EC番号 | 1.14.13.2 | ||||||||
| CAS登録番号 | 9059-23-8 | ||||||||
| データベース | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB構造 | RCSB PDB PDBj PDBe PDBsum | ||||||||
| 遺伝子オントロジー | AmiGO / QuickGO | ||||||||
| |||||||||
- 4-ヒドロキシ安息香酸 + NADPH + H+ + O2 プロトカテク酸 + NADP+ + H2O
反応式の通り、この酵素の基質は4-ヒドロキシ安息香酸とNADPHとH+とO2、生成物はプロトカテク酸とNADP+とH2Oである。補酵素としてFADを用いる。
組織名は4-hydroxybenzoate,NADPH:oxygen oxidoreductase (3-hydroxylating)で、別名にp-hydroxybenzoate hydrolyase、p-hydroxybenzoate hydroxylase、4-hydroxybenzoate 3-hydroxylase、4-hydroxybenzoate monooxygenase、4-hydroxybenzoic hydroxylase、p-hydroxybenzoate-3-hydroxylase、p-hydroxybenzoic acid hydrolase、p-hydroxybenzoic acid hydroxylase、p-hydroxybenzoic hydroxylaseがある。
参考文献 編集
- Hosokawa K, Stanier RY (1966). “Crystallization and properties of p-hydroxybenzoate hydroxylase from Pseudomonas putida”. J. Biol. Chem. 241 (10): 2453–60. PMID 4380381.
- Howell LG, Spector T, Massey V (1972). “Purification and properties of p-hydroxybenzoate hydroxylase from Pseudomonas fluorescens”. J. Biol. Chem. 247 (13): 4340–50. PMID 4402514.
- Spector T, Massey V (1972). “Studies on the effector specificity of p-hydroxybenzoate hydroxylase from Pseudomonas fluorescens”. J. Biol. Chem. 247 (14): 4679–87. PMID 4402938.
- Spector T, Massey V (1972). “p-Hydroxybenzoate hydroxylase from Pseudomonas fluorescens. Evidence for an oxygenated flavin intermediate”. J. Biol. Chem. 247 (17): 5632–6. PMID 4403446.
- Spector T, Massey V (1972). “p-Hydroxybenzoate hydroxylase from Pseudomonas fluorescens Reactivity with oxygen”. J. Biol. Chem. 247 (22): 7123–7. PMID 4404745.
- Seibold B, Matthes M, Eppink MH, Lingens F, Van Berkel WJ, Muller R (1996). “4-Hydroxybenzoate hydroxylase from Pseudomonas sp. CBS3 Purification, characterization, gene cloning, sequence analysis and assignment of structural features determining the coenzyme specificity”. Eur. J. Biochem. 239 (2): 469–78. doi:10.1111/j.1432-1033.1996.0469u.x. PMID 8706756.