RASGRP3

RASGRP3
識別子
記号	RASGRP3, GRP3, RAS guanyl releasing protein 3
外部ID	OMIM: 609531 MGI: 3028579 HomoloGene: 15019 GeneCards: RASGRP3
遺伝子の位置 (ヒト)
染色体	2番染色体 (ヒト)
終点	33,564,750 bp
遺伝子の位置 (マウス)
染色体	17番染色体 (マウス)
終点	75,836,049 bp
遺伝子オントロジー
分子機能	• calcium ion binding; • guanyl-nucleotide exchange factor activity; • GTPase activator activity; • シグナルトランスデューサー活性; • 金属イオン結合; • キナーゼ結合; • 血漿タンパク結合; • diacylglycerol binding;
細胞の構成要素	• 細胞質; • 細胞膜; • integral component of plasma membrane; • perinuclear region of cytoplasm; • guanyl-nucleotide exchange factor complex; • 細胞内;
生物学的プロセス	• intracellular signal transduction; • regulation of GTPase activity; • small GTPase mediated signal transduction; • MAPK cascade; • positive regulation of GTPase activity; • Ras protein signal transduction;
	出典:Amigo / QuickGO
オルソログ
	25780
	240168
	ENSG00000152689
	ENSMUSG00000071042
	Q8IV61,C9J9C9
	Q6NZH9
NM_001139488; NM_015376; NM_170672; NM_001349975; NM_001349976;
	NM_001349977; NM_001349978; NM_001349979; NM_001349980; NM_001349981
	NM_001166493; NM_207246; NM_001360103
NP_001132960; NP_056191; NP_733772; NP_001336904; NP_001336905;
	NP_001336906; NP_001336907; NP_001336908; NP_001336909; NP_001336910
	NP_001159965; NP_997129; NP_001347032
	ウィキデータ
閲覧/編集ヒト	閲覧/編集マウス

Rasグアニル放出タンパク質3（RAS guanyl-releasing protein 3、RasGRP3）は、ヒトのRASGRP3遺伝子にコードされているタンパク質である^[5]^[6]^[7]。

GTPアーゼのRASサブファミリーのメンバーは、シグナル伝達において不活性型であるGDP結合型と活性型のGTP結合型の間を循環するGTP/GDP-制御スイッチとして機能する。RASGRP3といったグアニンヌクレオチド交換因子 (GEF) は、GTP結合型を維持するためのGTPとの会合を促進することによってRAS活性化剤として働く。また、細胞膜受容体とRAS活性化の間の重要な役割を果たす。

相互作用編集

RASGRP3はPRKCDと相互作用することが明らかにされている^[8]。

脚注編集

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000152689 - Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000071042 - Ensembl, May 2017
^ Human PubMed Reference:
^ Mouse PubMed Reference:
^ Nagase T, Ishikawa K, Suyama M, Kikuno R, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (May 1999). “Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro”. DNA Res. 5 (6): 355–64. doi:10.1093/dnares/5.6.355. PMID 10048485.
^ Rebhun JF, Castro AF, Quilliam LA (Nov 2000). “Identification of guanine nucleotide exchange factors (GEFs) for the Rap1 GTPase. Regulation of MR-GEF by M-Ras-GTP interaction”. J. Biol. Chem. 275 (45): 34901–8. doi:10.1074/jbc.M005327200. PMID 10934204.
^ “Entrez Gene: RASGRP3 RAS guanyl releasing protein 3 (calcium and DAG-regulated)”. 2012年6月28日閲覧。
^ Brodie, Chaya; Steinhart Rivka, Kazimirsky Gila, Rubinfeld Hadara, Hyman Tehila, Ayres Jolene N, Hur Gang Min, Toth Attila, Yang Dazhi, Garfield Susan H, Stone James C, Blumberg Peter M (Jul. 2004). “PKCdelta associates with and is involved in the phosphorylation of RasGRP3 in response to phorbol esters”. Mol. Pharmacol. (United States) 66 (1): 76–84. doi:10.1124/mol.66.1.76. ISSN 0026-895X. PMID 15213298.

推薦文献編集

Hartley JL, Temple GF, Brasch MA (2001). “DNA Cloning Using In Vitro Site-Specific Recombination”. Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
Lorenzo PS, Kung JW, Bottorff DA, et al. (2001). “Phorbol esters modulate the Ras exchange factor RasGRP3”. Cancer Res. 61 (3): 943–9. PMID 11221888.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). “Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs”. Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). “Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Teixeira C, Stang SL, Zheng Y, et al. (2003). “Integration of DAG signaling systems mediated by PKC-dependent phosphorylation of RasGRP3”. Blood 102 (4): 1414–20. doi:10.1182/blood-2002-11-3621. PMID 12730099.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). “Complete sequencing and characterization of 21,243 full-length human cDNAs”. Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Brodie C, Steinhart R, Kazimirsky G, et al. (2004). “PKCdelta associates with and is involved in the phosphorylation of RasGRP3 in response to phorbol esters”. Mol. Pharmacol. 66 (1): 76–84. doi:10.1124/mol.66.1.76. PMID 15213298.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). “The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)”. Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Wiemann S, Arlt D, Huber W, et al. (2004). “From ORFeome to Biology: A Functional Genomics Pipeline”. Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
Aiba Y, Oh-hora M, Kiyonaka S, et al. (2004). “Activation of RasGRP3 by phosphorylation of Thr-133 is required for B cell receptor-mediated Ras activation”. Proc. Natl. Acad. Sci. U.S.A. 101 (47): 16612–7. doi:10.1073/pnas.0407468101. PMC 528733. PMID 15545601.
Roberts DM, Anderson AL, Hidaka M, et al. (2004). “A Vascular Gene Trap Screen Defines RasGRP3 as an Angiogenesis-Regulated Gene Required for the Endothelial Response to Phorbol Esters”. Mol. Cell. Biol. 24 (24): 10515–28. doi:10.1128/MCB.24.24.10515-10528.2004. PMC 533983. PMID 15572660.
Zheng Y, Liu H, Coughlin J, et al. (2005). “Phosphorylation of RasGRP3 on threonine 133 provides a mechanistic link between PKC and Ras signaling systems in B cells”. Blood 105 (9): 3648–54. doi:10.1182/blood-2004-10-3916. PMID 15657177.
Mehrle A, Rosenfelder H, Schupp I, et al. (2006). “The LIFEdb database in 2006”. Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
Okamura SM, Oki-Idouchi CE, Lorenzo PS (2007). “The exchange factor and diacylglycerol receptor RasGRP3 interacts with dynein light chain 1 through its C-terminal domain”. J. Biol. Chem. 281 (47): 36132–9. doi:10.1074/jbc.M605093200. PMID 17012239.
Ewing RM, Chu P, Elisma F, et al. (2007). “Large-scale mapping of human protein–protein interactions by mass spectrometry”. Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
Randhawa PK, Rylova S, Heinz JY, et al. (2011). “The Ras Activator RasGRP3 Mediates Diabetes-Induced Embryonic Defects and Affects Endothelial Cell Migration”. Circ Res. 108 (10): 1199–1208. doi:10.1161/CIRCRESAHA.110.230888. PMID 21474816.

この項目は、生物学に関連した書きかけの項目です。この項目を加筆・訂正などしてくださる協力者を求めています（プロジェクト:生命科学／Portal:生物学）。

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000152689 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000071042 - Ensembl, May 2017

[3] Human PubMed Reference:

[4] Mouse PubMed Reference:

[pmid10048485-5] Nagase T, Ishikawa K, Suyama M, Kikuno R, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (May 1999). “Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro”. DNA Res. 5 (6): 355–64. doi:10.1093/dnares/5.6.355. PMID 10048485.

[pmid10934204-6] Rebhun JF, Castro AF, Quilliam LA (Nov 2000). “Identification of guanine nucleotide exchange factors (GEFs) for the Rap1 GTPase. Regulation of MR-GEF by M-Ras-GTP interaction”. J. Biol. Chem. 275 (45): 34901–8. doi:10.1074/jbc.M005327200. PMID 10934204.

[entrez-7] “Entrez Gene: RASGRP3 RAS guanyl releasing protein 3 (calcium and DAG-regulated)”. 2012年6月28日閲覧。

[pmid15213298-8] Brodie, Chaya; Steinhart Rivka, Kazimirsky Gila, Rubinfeld Hadara, Hyman Tehila, Ayres Jolene N, Hur Gang Min, Toth Attila, Yang Dazhi, Garfield Susan H, Stone James C, Blumberg Peter M (Jul. 2004). “PKCdelta associates with and is involved in the phosphorylation of RasGRP3 in response to phorbol esters”. Mol. Pharmacol. (United States) 66 (1): 76–84. doi:10.1124/mol.66.1.76. ISSN 0026-895X. PMID 15213298.

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RASGRP3

相互作用 編集

脚注 編集

推薦文献 編集

相互作用編集

脚注編集

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