Template:PBB/3976

Leukemia inhibitory factor
PDB rendering based on 1LKI.
PDBに登録されている構造 PDB Ortholog search: PDBe, RCSB, PDBj PDBのIDコード一覧 1EMR​, 1PVH​, 2Q7N​
識別記号
記号	LIF; CDF; DIA; HILDA; MLPLI
その他ID	OMIM: 159540 MGI: 96787 HomoloGene: 1734 GeneCards: LIF Gene
遺伝子オントロジー 分子機能 • RNA polymerase II transcription factor recruiting transcription factor activity • receptor binding • cytokine activity • leukemia inhibitory factor receptor binding • growth factor activity 細胞の構成要素 • extracellular space • cytoplasm 生物学的プロセス • blood vessel remodeling • immune response • multicellular organismal development • embryo implantation • positive regulation of cell proliferation • negative regulation of cell proliferation • stem cell maintenance • positive regulation of peptidyl-serine phosphorylation • positive regulation of peptidyl-serine phosphorylation of STAT protein • tyrosine phosphorylation of Stat3 protein • positive regulation of tyrosine phosphorylation of Stat1 protein • positive regulation of tyrosine phosphorylation of Stat3 protein • positive regulation of MAPK cascade • positive regulation of macrophage differentiation • negative regulation of meiosis • positive regulation of transcription from RNA polymerase II promoter • decidualization • negative regulation of hormone secretion • lung alveolus development • muscle organ morphogenesis • neuron development • positive regulation of astrocyte differentiation • leukemia inhibitory factor signaling pathway • positive regulation of peptidyl-tyrosine phosphorylation • lung vasculature development • lung lobe morphogenesis • trophoblast giant cell differentiation • spongiotrophoblast differentiation • negative regulation of ERK1 and ERK2 cascade • positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis • regulation of metanephric nephron tubule epithelial cell differentiation • positive regulation of protein localization to nucleus • positive regulation of histone H3-K27 acetylation 出典: Amigo / EGO
RNA発現パターン
その他参照発現データ
オルソログ
種	ヒト	マウス
Entrez	3976	16878
Ensembl	ENSG00000128342	ENSMUSG00000034394
UniProt	P15018	P09056
RefSeq (mRNA)	NM_001257135	NM_001039537
RefSeq (protein)	NP_001244064	NP_001034626
Location (UCSC)	Chr 22: 30.64 - 30.64 Mb	Chr 11: 4.26 - 4.27 Mb
PubMed search	[1]	[2]
KEGG GENES	hsa:3976	mmu:16878