リシニン
リシニン(Ricinine)は、トウゴマ(Ricinus)に含まれる毒性アルカロイドである[2]。リシン中毒のバイオマーカーになりうる[3][4]。
| Ricinine | |
|---|---|
| |
4-Methoxy-1-methyl-2-oxo-1,2-dihydro-3-pyridinecarbonitrile | |
別称 3-cyano-4-methoxy-N-methyl-2-pyridone | |
| 識別情報 | |
| CAS登録番号 | 524-40-3 |
| PubChem | 10666 |
| ChemSpider | 10216 |
| UNII | 130UFS7AE0 |
| EC番号 | 208-359-7 |
| KEGG | C01526 |
| ChEBI | |
| ChEMBL | CHEMBL1329957 |
| 3DMet | B00311 |
| |
| |
| 特性 | |
| 化学式 | C8H8N2O2 |
| モル質量 | 164.16 g mol−1 |
| 融点 |
200 °C, 473 K, 392 °F |
| 危険性 | |
| 半数致死量 LD50 | 340 mg/kg[1] |
| 特記なき場合、データは常温 (25 °C)・常圧 (100 kPa) におけるものである。 | |
関連項目 編集
出典 編集
- ^ Worbs, Sylvia; Kohler, Kernt; Pauly, Diana; Avondet, Marc-Andre; Schaer, Martin; Dorner, Martin B.; Dorner, Brigitte G. (24 October 2011). “Ricinus communis Intoxications in Human and Veterinary Medicine-A Summary of Real Cases”. Toxins 3 (10): 1332-1372. doi:10.3390/toxins3101332. PMC 3210461. PMID 22069699.
- ^ Peng, Jing; Cai, Shuang; Wang, Lin; Zhao, Nan; Zhang, Ting-jian; Chen, Zai-xing; Meng, Fan-hao; Dzeja, Petras (11 March 2014). “A Metabonomic Analysis of Serum from Rats Treated with Ricinine Using Ultra Performance Liquid Chromatography Coupled with Mass Spectrometry”. PLoS ONE 9 (3): e90416. Bibcode: 2014PLoSO...990416P. doi:10.1371/journal.pone.0090416. PMC 3949718. PMID 24618672.
- ^ Hamelin, Elizabeth I.; Johnson, Rudolph C.; Osterloh, John D.; Howard, David J.; Thomas, Jerry D. (November 2012). “Evaluation of Ricinine, a Ricin Biomarker, from a Non-Lethal Castor Bean Ingestion”. Journal of Analytical Toxicology 36 (9): 660-662. doi:10.1093/jat/bks077. PMC 4561852. PMID 23014889.
- ^ Pittman, C. T.; Guido, J. M.; Hamelin, E. I.; Blake, T. A.; Johnson, R. C. (6 March 2013). “Analysis of a Ricin Biomarker, Ricinine, in 989 Individual Human Urine Samples”. Journal of Analytical Toxicology 37 (4): 237-240. doi:10.1093/jat/bkt010. PMC 4547525. PMID 23471955.
- ^ Wachira, Sabina; Omar, Sabar; Jacob, Julia; Wahome, Martin; Alborn, Hans T; Spring, David R; Masiga, Daniel K; Torto, Baldwyn (2014). “Toxicity of six plant extracts and two pyridone alkaloids from Ricinus communis against the malaria vector Anopheles gambiae”. Parasites & Vectors 7 (1): 312. doi:10.1186/1756-3305-7-312. PMC 4098926. PMID 24996560.