「アセチルサリチル酸」の版間の差分

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Skirtick (会話 | 投稿記録)
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{{Infobox drug
{{Chembox
| Watchedfields = changed
|Name=アセチルサリチル酸
| verifiedrevid = 464364671
|ImageFile=Aspirin-skeletal.svg
| IUPAC_name = 2-(acetoxy)benzoic acid <!-- per ChemSpider -->
|ImageSize=150px
| OtherNames = Acetylsalicylic acid
|ImageAlt=アセチルサリチル酸の構造式
|ImageFile1 image = Aspirin-B-3D-ballsskeletal.pngsvg
| image2 = Aspirin-B-3D-balls.png
|ImageSize1=150px
 
|ImageAlt1=アセチルサリチル酸のスティックモデル
<!--Clinical data-->
|IUPACName=2-アセトキシ安息香酸<br />2-エタノイルオキシベンゼンカルボン酸
| Drugs.com = {{drugs.com|monograph|aspirin}}
|OtherNames=アスピリン
| MedlinePlus = a682878
|Section1={{Chembox Identifiers
| pregnancy_AU = C
|CASNo=50-78-2
| pregnancy_US = C
|KEGG=D00109
| pregnancy_US_comment= 三ヶ月後はD
}}
| legal_AU = S2
|Section2={{Chembox Properties
| legal_UK = GSL
|Formula=C<sub>9</sub>H<sub>8</sub>O<sub>4</sub>
| legal_US = OTC
|MolarMass=180.16
| routes_of_administration = 通常は経口
|Appearance=無色固体
 
|Density=1.40, 固体
<!--Pharmacokinetic data-->
|MeltingPt=136
| bioavailability = 80–100%<ref name = MSR>{{cite web|title=Zorprin, Bayer Buffered Aspirin (aspirin) dosing, indications, interactions, adverse effects, and more|work=Medscape Reference|publisher=WebMD|accessdate=3 April 2014|url=http://reference.medscape.com/drug/zorprin-bayer-buffered-aspirin-343279#showall}}</ref>
|Melting_notes=
| protein_bound = 80–90%<ref name = MD>{{cite web|title=Aspirin|work=Martindale: The Complete Drug Reference|publisher=Pharmaceutical Press|date=14 January 2014|accessdate=3 April 2014|url=http://www.medicinescomplete.com/mc/martindale/current/2601-s.htm|editor=Brayfield, A}}</ref>
|BoilingPt=
| metabolism = [[肝臓]], ([[CYP2C19]] と [[CYP3A]]), 一部は腸壁にサリチル酸塩に加水分解する.<ref name = MD/>
|Boiling_notes=
| elimination_half-life = 低用量のときは2-3時間、高用量のときは15-30時間<ref name = MD/>
|Solubility=0.46 g/100mL (20 {{℃}})
| excretion = 尿(80〜100%)、汗、唾液、糞便<ref name = MSR/>
|SolubleOther=
 
|Solvent=
<!--Identifiers-->
|pKa=3.49 (25 {{℃}})
| CAS_number_Ref = {{cascite|correct|??}}
|pKb=
|CASNo CAS_number = 50-78-2
}}
| ATC_prefix = A01
| ATC_suffix = AD05
| ATC_supplemental = {{ATC|B01|AC06}}, {{ATC|N02|BA01}}
| PubChem = 2244
| DrugBank_Ref = {{drugbankcite|correct|drugbank}}
| DrugBank = DB00945
| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}
| ChemSpiderID = 2157
| UNII_Ref = {{fdacite|correct|FDA}}
| UNII = R16CO5Y76E
| KEGG_Ref = {{keggcite|correct|kegg}}
| KEGG = D00109
| ChEBI_Ref = {{ebicite|correct|EBI}}
| ChEBI = 15365
| ChEMBL_Ref = {{ebicite|correct|EBI}}
| ChEMBL = 25
| PDB_ligand = AIN
<!--Chemical data-->
| C=9 | H=8 | O=4
| molecular_weight = 180.157 g/mol
| smiles = O=C(Oc1ccccc1C(=O)O)C
| InChI = 1/C9H8O4/c1-6(10)13-8-5-3-2-4-7(8)9(11)12/h2-5H,1H3,(H,11,12)
| StdInChI_Ref = {{stdinchicite|correct|chemspider}}
| StdInChI = 1S/C9H8O4/c1-6(10)13-8-5-3-2-4-7(8)9(11)12/h2-5H,1H3,(H,11,12)
| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}}
| StdInChIKey = BSYNRYMUTXBXSQ-UHFFFAOYSA-N
| synonyms = 2-acetoxybenzoic acid<br />acetylsalicylate<br />acetylsalicylic acid<br />O-acetylsalicylic acid
| density = 1.40
| melting_point = 135
| boiling_point = 140
| boiling_notes = (分解)
| solubility = 3
}}