「アフラトキシンB1」の版間の差分

アフラトキシンB<SUB>1</SUB>は、ヒトにおいては経口からの摂取が主であるが、皮膚も透過し得る。そしてそれが重大な健康上のリスクにつながる可能性がある<ref>{{Cite journal | pmid = 22749975 | title = Human skin penetration of selected model mycotoxins | year = 2012 | last1 = Boonen| first1 = Jente| last2 = Malysheva| first2 = Svetlana V.| last3 = Taevernier| first3 = Lien| last4 = Diana Di Mavungu| first4 = José| last5 = De Saeger | first5 = Sarah| last6 = De Spiegeleer | first6 = Bart| journal = Toxicology| volume = 301 | issue = 1–3 | pages = 21–32 | doi=10.1016/j.tox.2012.06.012}}</ref>。アフラトキシンB<SUB>1</SUB>の毒性に対して最も感受性が高い臓器は肝臓であり、動物実験における病変には、肝臓重量の低下<ref name="FernándezRamos1996">{{cite journal|last1=Fernández|first1=Antonio|last2=Ramos|first2=Juan José|last3=Sanz|first3=María del Carmen|last4=Saez|first4=Teófilo|last5=Luco|first5=Daniel Fernández de|title=Alterations in the Performance, Haematology and Clinical Biochemistry of Growing Lambs Fed with Aflatoxin in the Diet|journal=J. Appl. Toxicol. |volume=16|issue=1|year=1996|pages=85–91|pmid= 8821681 |doi=10.1002/(SICI)1099-1263(199601)16:1<85::AID-JAT315>3.0.CO;2-T}}</ref>、肝細胞の空胞化<ref name="EspadaDomingo1992">{{cite journal|last1=Espada|first1=Y.|last2=Domingo|first2=M.|last3=Gomez|first3=J.|last4=Calvo|first4=M.A.|title=Pathological lesions following an experimental intoxication with aflatoxin B₁ in broiler chickens|journal=Res. Vet. Sci. |volume=53|issue=3|year=1992|pages=275–279|pmid= 1465501 |doi=10.1016/0034-5288(92)90127-N}}</ref>、肝細胞癌 <ref name=":0">{{cite journal | author = Larsson P, Busk L, Tjälve H | year = 1994 | title = Hepatic and extrahepatic bioactivation and GSH conjugation of aflatoxin B1 in sheep | url = | journal = Carcinogenesis | volume = 15 | issue = 5| pages = 947–55 | doi=10.1093/carcin/15.5.947| pmid = 8200100 }}</ref>などがある。また肝細胞の肥大、[[脂肪肝]]、[[壊死]]、出血、[[肝線維症]]、結節の再生、胆管の増殖や[[過形成]]なども認められる<ref>{{cite book|author=Patterson D.S.P.|chapter= Aflatoxin and related compounds: Introduction|editor= Wyllie T.D., Morehouse L.G.|title= Mycotoxic Fungi, Mycotoxins, Mycotoxicoses, an Encyclopaedic Handbook. 1st. Vol. 1. |publisher=Marcel Dekker Inc.|location= New York, NY, USA|year= 1977|pages= 131–135|isbn=978-0824765507}}</ref>。