芳香族炭化水素受容体核内輸送体

芳香族炭化水素受容体核内輸送体（ARNT: aryl hydrocarbon receptor nuclear translocator）は、リガンド結合型芳香族炭化水素受容体（AhR）と複合体を形成するタンパク質であり、AhRが受容体として機能するために必要である。また、低酸素誘導因子1（HIF1）のベータサブユニットとしても知られている。TEL-ARNT融合タンパク質の発現をもたらす遺伝子座のt(1; 12)(q21; p13)転座は、急性骨髄芽球性白血病と関連している。この遺伝子について、異なるアイソフォームをコードする3つのスプライスバリアントが報告されている。

ARNT
PDBに登録されている構造 PDB オルソログ検索: RCSB PDBe PDBj PDBのIDコード一覧 4PKY, 1X0O, 2A24, 2B02, 2HV1, 2K7S, 3F1N, 3F1O, 3F1P, 3H7W, 3H82, 4EQ1, 4GHI, 4GS9, 4H6J, 4LPZ, 4XT2
識別子
記号	ARNT, HIF-1-beta, HIF-1beta, HIF1-beta, HIF1B, HIF1BETA, TANGO, bHLHe2, aryl hydrocarbon receptor nuclear translocator, Aryl hydrocarbon receptor nuclear translocator
外部ID	OMIM: 126110 MGI: 88071 HomoloGene: 1261 GeneCards: ARNT
遺伝子の位置 (ヒト) 染色体 1番染色体 (ヒト) バンド データ無し 開始点 150,809,713 bp 終点 150,876,708 bp
遺伝子の位置 (マウス) 染色体 3番染色体 (マウス) バンド データ無し 開始点 95,341,699 bp 終点 95,404,551 bp
RNA発現パターン さらなる参照発現データ
遺伝子オントロジー 分子機能 • sequence-specific DNA binding • DNA結合 • protein dimerization activity • DNA-binding transcription factor activity • transcription coactivator activity • aryl hydrocarbon receptor binding • 転写因子結合 • 血漿タンパク結合 • protein heterodimerization activity • transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding • DNA-binding transcription factor activity, RNA polymerase II-specific • protein homodimerization activity • sequence-specific double-stranded DNA binding • nuclear receptor activity 細胞の構成要素 • 細胞質 • transcription regulator complex • 核質 • RNA polymerase II transcription regulator complex • 細胞核 • 核内構造体 生物学的プロセス • positive regulation of vascular endothelial growth factor receptor signaling pathway • 細胞分化 • 低酸素症への反応 • regulation of transcription, DNA-templated • positive regulation of endothelial cell proliferation • regulation of transcription from RNA polymerase II promoter in response to oxidative stress • positive regulation of erythrocyte differentiation • embryonic placenta development • mRNA transcription by RNA polymerase II • positive regulation of protein sumoylation • transcription, DNA-templated • positive regulation of transcription, DNA-templated • intracellular receptor signaling pathway • regulation of transcription from RNA polymerase II promoter in response to hypoxia • positive regulation of vascular endothelial growth factor production • positive regulation of glycolytic process • positive regulation of transcription by RNA polymerase II • positive regulation of hormone biosynthetic process • 生体異物の代謝プロセス 出典:Amigo / QuickGO
オルソログ
種	ヒト	マウス
Entrez	405	11863
Ensembl	ENSG00000143437	ENSMUSG00000015522
UniProt	P27540	P53762
RefSeq (mRNA)	NM_001197325 NM_001286035 NM_001286036 NM_001668 NM_178426 NM_178427 NM_001350224 NM_001350225 NM_001350226	NM_001037737 NM_009709
RefSeq (タンパク質)	NP_001184254 NP_001272964 NP_001272965 NP_001659 NP_848514 NP_001337153 NP_001337154 NP_001337155	NP_001032826 NP_033839
場所 (UCSC)	Chr 1: 150.81 – 150.88 Mb	Chr 1: 95.34 – 95.4 Mb
PubMed検索
ウィキデータ
閲覧/編集 ヒト 閲覧/編集 マウス

AhRは、生体異物代謝に関与するいくつかの酵素の誘導に関与している。リガンドを含まない、細胞質ゾル型のAhRは、熱ショックタンパク質90（Hsp90）と複合体を形成する。ダイオキシンと多環芳香族炭化水素を含むリガンドの結合は、リガンド結合サブユニットの核への転座をもたらす。生体異物代謝に関与する酵素の誘導は、これら酵素の遺伝子のプロモーター内の生体異物応答エレメントへのリガンド結合型AhRの結合を介して発生する。

相互作用分子

ARNTは、以下の生体分子と相互作用する。

• 芳香族炭化水素受容体相互作用タンパク質（AIP）
• 芳香族炭化水素受容体（AHR）
• 内皮PASドメイン含有タンパク質（EPAS1）
• 低酸素誘導因子1A（HIF1A）
• 核内受容体コアクチベーター2（NCOA2）
• SIM1
• SIM2

参考文献

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外部リンク

• Aryl Hydrocarbon Receptor Nuclear Translocator - MeSH・アメリカ国立医学図書館・生命科学用語シソーラス（英語）