EZH1
ヒストン-リジン-N-メチルトランスフェラーゼEZH1（enhancer of zeste homolog 1）は、ヒトではEZH1遺伝子にコードされるタンパク質である[5][6]。
機能 編集
マウスでは、EZH1とEZH2は共にヒストンH3K27のトリメチル化を司り、毛包の恒常性と創傷治癒に必要不可欠である[7]。またEZH1は、幹細胞の同一性の維持と多能性の発揮に関するEZH2の機能を補完する[8]。
出典 編集
- ^ a b c GRCh38: Ensembl release 89: ENSG00000108799 - Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000006920 - Ensembl, May 2017
- ^ Human PubMed Reference:
- ^ Mouse PubMed Reference:
- ^ “Characterization of EZH1, a human homolog of Drosophila Enhancer of zeste near BRCA1”. Genomics 37 (2): 161–71. (Feb 1997). doi:10.1006/geno.1996.0537. PMID 8921387.
- ^ “Entrez Gene: EZH1 enhancer of zeste homolog 1 (Drosophila)”. 2021年9月5日閲覧。
- ^ “EZH1 and EZH2 cogovern histone H3K27 trimethylation and are essential for hair follicle homeostasis and wound repair.”. Genes Dev. 25 (5): 485–98. (Mar 2011). doi:10.1101/gad.2019811. PMC 3049289. PMID 21317239.
- ^ “EZH1 mediates methylation on histone H3 lysine 27 and complements EZH2 in maintaining stem cell identity and executing pluripotency.”. Mol Cell 32 (4): 491–502. (Nov 2008). doi:10.1016/j.molcel.2008.10.016. PMC 2630502. PMID 19026780.
関連文献 編集
- “Generation of a transcription map at the HSD17B locus centromeric to BRCA1 at 17q21.”. Genomics 28 (3): 530–42. (1996). doi:10.1006/geno.1995.1185. PMID 7490091.
- “Construction of a transcription map surrounding the BRCA1 locus of human chromosome 17.”. Genomics 25 (1): 238–47. (1995). doi:10.1016/0888-7543(95)80131-5. PMID 7774924.
- “Direct selection of expressed sequences within a 1-Mb region flanking BRCA1 on human chromosome 17q21.”. Genomics 25 (1): 248–55. (1995). doi:10.1016/0888-7543(95)80132-6. PMID 7774925.
- “22 genes from chromosome 17q21: cloning, sequencing, and characterization of mutations in breast cancer families and tumors.”. Genomics 25 (1): 256–63. (1995). doi:10.1016/0888-7543(95)80133-7. PMID 7774926.
- “Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.”. DNA Res. 4 (2): 141–50. (1997). doi:10.1093/dnares/4.2.141. PMID 9205841.
- “Cloning and expression of a human/mouse Polycomb group gene, ENX-2/Enx-2.”. Biochim. Biophys. Acta 1395 (2): 151–8. (1998). doi:10.1016/s0167-4781(97)00156-5. PMID 9473645.
- “The Drosophila esc and E(z) proteins are direct partners in polycomb group-mediated repression.”. Mol. Cell. Biol. 18 (5): 2825–34. (1998). doi:10.1128/mcb.18.5.2825. PMC 110661. PMID 9566901.
- “Interaction of mouse polycomb-group (Pc-G) proteins Enx1 and Enx2 with Eed: indication for separate Pc-G complexes.”. Mol. Cell. Biol. 18 (6): 3572–9. (1998). doi:10.1128/MCB.18.6.3572. PMC 108938. PMID 9584197.
- “Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. (2003). doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”. Genome Res. 14 (10B): 2121–7. (2004). doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
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