ペプチド性メチオニン(S)-S-オキシドレダクターゼ
ペプチド性メチオニン(S)-S-オキシドレダクターゼ（peptide-methionine (S)-S-oxide reductase）は、次の化学反応を触媒する酸化還元酵素である。
| ペプチド性メチオニン(S)-S-オキシドレダクターゼ | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| 識別子 | |||||||||
| EC番号 | 1.8.4.11 | ||||||||
| データベース | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB構造 | RCSB PDB PDBj PDBe PDBsum | ||||||||
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- (1) ペプチド-L-メチオニン + チオレドキシンジスルフィド + H2O ペプチド-L-メチオニン-(S)-S-オキシド + チオレドキシン
- (2) L-メチオニン + チオレドキシンジスルフィド + H2O L-メチオニン(S)-S-オキシド + チオレドキシン
組織名はpeptide-L-methionine:thioredoxin-disulfide S-oxidoreductase [L-methionine (S)-S-oxide-forming]で、別名にMsrA、methionine sulfoxide reductase (ambiguous)、methionine sulphoxide reductase A、methionine S-oxide reductase (ambiguous)、methionine S-oxide reductase (S-form oxidizing)、methionine sulfoxide reductase A、peptide methionine sulfoxide reductaseがある。
参考文献 編集
- Moskovitz, J., Singh, V.K., Requena, J., Wilkinson, B.J., Jayaswal, R.K. and Stadtman, E.R. (2002). “Purification and characterization of methionine sulfoxide reductases from mouse and Staphylococcus aureus and their substrate stereospecificity.”. Biochem. Biophys. Res. Commun. 290: 62-65. PMID 11779133.
- Taylor, A.B., Benglis, D.M., Jr., Dhandayuthapani, S. and Hart, P.J. (2003). “Structure of Mycobacterium tuberculosis methionine sulfoxide reductase A in complex with protein-bound methionine.”. J. Bacteriol. 185: 4119-4126. PMID 12837786.
- Singh, V.K. and Moskovitz, J. (2003). “Multiple methionine sulfoxide reductase genes in Staphylococcus aureus: expression of activity and roles in tolerance of oxidative stress.”. Microbiology 149: 2739-2747. PMID 14523107.
- Boschi-Muller, S., Olry, A., Antoine, M. and Branlant, G. (2005). “The enzymology and biochemistry of methionine sulfoxide reductases.”. Biochim. Biophys. Acta 1703: 231-238. PMID 15680231.
- Ezraty, B., Aussel, L. and Barras, F. (2005). “Methionine sulfoxide reductases in prokaryotes.”. Biochim. Biophys. Acta 1703: 221-229. PMID 15680230.
- Weissbach, H., Resnick, L. and Brot, N. (2005). “Methionine sulfoxide reductases: history and cellular role in protecting against oxidative damage.”. Biochim. Biophys. Acta 1703: 203-212. PMID 15680228.
- Kauffmann, B., Aubry, A. and Favier, F. (2005). “The three-dimensional structures of peptide methionine sulfoxide reductases: current knowledge and open questions.”. Biochim. Biophys. Acta 1703: 249-260. PMID 15680233.
- Vougier, S., Mary, J. and Friguet, B. (2003). “Subcellular localization of methionine sulphoxide reductase A (MsrA): evidence for mitochondrial and cytosolic isoforms in rat liver cells.”. Biochem. J. 373: 531-537. PMID 12693988.
- Olry, A., Boschi-Muller, S., Marraud, M., Sanglier-Cianferani, S., Van Dorsselear, A. and Branlant, G. (2002). “Characterization of the methionine sulfoxide reductase activities of PILB, a probable virulence factor from Neisseria meningitidis.”. J. Biol. Chem. 277: 12016-12022. PMID 11812798.
- Boschi-Muller, S., Olry, A., Antoine, M. and Branlant, G. (2005). “The enzymology and biochemistry of methionine sulfoxide reductases.”. Biochim. Biophys. Acta 1703: 231-238. PMID 15680231.
- Brot, N., Weissbach, L., Werth, J. and Weissbach, H. (1981). “Enzymatic reduction of protein-bound methionine sulfoxide.”. Proc. Natl. Acad. Sci. USA 78: 2155-2158. PMID 7017726.